Oliwia

Venous organoids · Live-cell imaging

Long-term
treatment videos.

Brightfield imaging across the complete differentiation time course, from iPSCs through venous endothelial-like cells (VLECs).

Differentiation workflow and long- and short-term inhibitor treatment timeline, including inhibitor addition and replenishment times.
Images every 4 hours · 38 timepoints

PS, primitive streak · LPM, lateral plate mesoderm · VD1, venous induction day 1 · VD2, venous induction day 2 · VLECs, venous-like endothelial cells

Comparison of alpelisib inhibition in wild-type and mutant cells with zovegalisib preferential inhibition in PIK3CA H1047R mutant cells.

Video collection

Compare treatments.

Alpelisib (BYL719) and zovegalisib (RLY-2608) are shown across the full 38-timepoint sequence, with the Vehicle reference held alongside.

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